Researchers rely on cell lines as a model system for basic
research, standards, and control. The most influential obstacle to
cell culture is the contamination caused by the following reasons,
including cross-contamination with other cell lines, chromosomal
stability, and microbial contamination. As awareness of cell line
contamination or misidentification increases, researchers are
required to ensure the identity and purity of their cell lines. The
most convenient method for the identification of potential
cross-contamination of cell lines of different species is to
combine karyotype analysis with microscopes of different
resolutions. Cytogenetic methods offer the greatest hope for
species verification because they are easy to use and
cost-effective. In addition, karyotype and chromosome analysis also
provide help for researchers in the development and establishment
of new cell lines. Karyotyping methods that can be used for cell
line development and identification include G-band karyotyping,
fluorescence in situ hybridization (FISH), spectral karyotyping
(SKY), and comparative genomic hybridization (CGH). Our analysis
platform can provide comprehensive karyotype and
chromosome analysis solutions for cell line
characterization.
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