#6 new
Hannah Cole

Karyotyping and Chromosome Analysis

Reported by Hannah Cole | July 23rd, 2024 @ 08:25 AM

Researchers rely on cell lines as a model system for basic research, standards, and control. The most influential obstacle to cell culture is the contamination caused by the following reasons, including cross-contamination with other cell lines, chromosomal stability, and microbial contamination. As awareness of cell line contamination or misidentification increases, researchers are required to ensure the identity and purity of their cell lines. The most convenient method for the identification of potential cross-contamination of cell lines of different species is to combine karyotype analysis with microscopes of different resolutions. Cytogenetic methods offer the greatest hope for species verification because they are easy to use and cost-effective. In addition, karyotype and chromosome analysis also provide help for researchers in the development and establishment of new cell lines. Karyotyping methods that can be used for cell line development and identification include G-band karyotyping, fluorescence in situ hybridization (FISH), spectral karyotyping (SKY), and comparative genomic hybridization (CGH). Our analysis platform can provide comprehensive karyotype and chromosome analysis solutions for cell line characterization.

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